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HZI researchers investigated the formation of signalling substances in Pseudomonas and discovered a target for novel medications The hospital germ Pseudomonas aeruginosa can cause serious wound as well as lung and urinary tract infections, especially in weakened individuals. Print Send per email Share. The detail enlargement shows that the channel has an optimal length for binding a fatty acid chain of eight carbon atoms. Where immunological synapses are correctly formed, the receptor molecules are concentrated around a central point whereas the other surface proteins arrange themselves into two rings around this central area. HZI researchers have investigated the formation of immunological synapses over which immune cells exchange information The immune system protects the human body against pathogens thus keeping it healthy.

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  • Press Release – Helmholtz Zentrum München

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    Computer simulations can be used to derive a dynamic mechanism from these states, in which PqsBC can bind to the fatty acid chain by closing the molecule.

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    If an immune cell recognises foreign matter, it can present it to another immune cell. The hospital germ Pseudomonas aeruginosa can cause serious wound as well as lung and urinary tract infections, especially in weakened individuals. The scientists published their results in ChemBioChem.

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    Print Send per email Share. Pseudomonas bacteria can colonise and proliferate in virtually any environment, including the lungs, eyes, urinary tract, an open wound or an implant.

    images best free dating apps for iphone 2013
    Best free dating apps for iphone 2013
    In this way, activation of T-cells may be induced or slowed down, which could be used for improved management of acute or chronic infections, improved results from vaccination or prevention of autoimmune diseases.

    Press Release – Helmholtz Zentrum München

    Pseudomonas manages time and again to survive attacks of the immune system and antibiotic therapies. Print Send per email Share. The hospital germ Pseudomonas aeruginosa can cause serious wound as well as lung and urinary tract infections, especially in weakened individuals. HZI researchers investigated the formation of signalling substances in Pseudomonas and discovered a target for novel medications The hospital germ Pseudomonas aeruginosa can cause serious wound as well as lung and urinary tract infections, especially in weakened individuals.

    Pseudomonas bacteria can colonise and proliferate in virtually any environment, including the lungs, eyes, urinary tract, an open wound or an implant.

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    with this carbon chain is the one that is best recognised by the receptor of the.
    The three-dimensional structure of the protein complex also demonstrates that the length of the channel is such that it is filled up by a fatty acid chain consisting of eight carbon atoms. To do this, T-cells make contact with the antigen-presenting immune cells and read information from their surface.

    If all the components of the synapse are correctly positioned, activation of the immune cell will result. Print Send per email Share. HZI researchers investigated the formation of signalling substances in Pseudomonas and discovered a target for novel medications The hospital germ Pseudomonas aeruginosa can cause serious wound as well as lung and urinary tract infections, especially in weakened individuals.

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    In these models, they simulated different conditions and influencing factors and were able to demonstrate that the different molecules exert an influence on each other in terms of their arrangement although they do not interact directly.

    HZI researchers investigated the formation of signalling substances in Pseudomonas and discovered a target for novel medications The hospital germ Pseudomonas aeruginosa can cause serious wound as well as lung and urinary tract infections, especially in weakened individuals. Anastasios Siokis, Philippe A. The immune system protects the human body against pathogens thus keeping it healthy. PqsBC exists in different conformational states.

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    1. This cell type is responsible for classifying the presented parts as dangerous or harmless and, if necessary, initiating a response against them.

    2. From a medical point of view, these results are of particular significance for the area of treatment of defective T-cell activity. If we manage to freeze the mobility of PqsBC with an agent, we would be able to specifically inhibit PqsBC and disrupt the communication of P.